Our paper titled “Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice” was published in Molecular Metabolism. demonstrate that partial loss of skeletal muscle-specific Drp1 expression is sufficient to improve whole-body glucose homeostasis and insulin sensitivity under obese, insulin-resistant conditions, which may be, at least in part, due to reduced mitochondrial H2O2 production. In addition, our findings revealed divergent effects of Drp1 on whole-body metabolism under lean healthy or obese insulin-resistant conditions in mice.
Years of work lead by former doctoral student Benjamin Kugler and finished by current students Jared Lourie, Nicolas Berger and Grace Rosen. The article is freely available at https://pubmed.ncbi.nlm.nih.gov/37690520/